Characterization of Gene Interaction and Assessment of LD Matrix Measures for the Analysis of Biological Pathway Association
نویسندگان
چکیده
Computational Biology & Bioinformatics) Characterization of Gene Interaction and Assessment of LD Matrix Measures for the Analysis of Biological Pathway Association by David R. Crosslin Department of Computational Biology & Bioinformatics Duke University
منابع مشابه
Genome-wide Association Study to Identify Genes and Biological Pathways Associated with Type Traits in Cattle using Pathway Analysis
Extended Abstract Introduction and Objective: Type traits describing the skeletal characteristics of an animal are moderately to strongly genetically correlate with other economically important traits in cattle including fertility, longevity and carcass traits. The present study aimed to conduct a genome wide association studies (GWAS) based on gene-set enrichment analysis for identifying the ...
متن کاملThe role of MMP9 C-1562T and MMP2 G1575A genetic variants in male infertility: review article
Infertility as a vital process in human reproduction involves many couples worldwide. Although many genetic causes of infertility are known, the genetic basis of infertility in men is largely unknown. Therefore, the identification of genetic biomarkers in this field is important and genetic polymorphisms in key genes of the spermatogenesis pathway can be valuable biomarkers in this field. Gene'...
متن کاملAssessment of LD matrix measures for the analysis of biological pathway association.
Complex diseases will have multiple functional sites, and it will be invaluable to understand the cross-locus interaction in terms of linkage disequilibrium (LD) between those sites (epistasis) in addition to the haplotype-LD effects. We investigated the statistical properties of a class of matrix-based statistics to assess this epistasis. These statistical methods include two LD contrast tests...
متن کاملFunctional Assessment of CODM Gene in Different Cultivar of Papaveraceous Species Via In Silico Analysis
Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...
متن کاملFunctional Assessment of CODM Gene in Different Cultivar of Papaveraceous Species Via In Silico Analysis
Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...
متن کامل